Medications

Important Notice

This page provides general guidance only. Aviation medical decisions are made on a case-by-case basis by Transport Canada and a CAME.

Taking Medications as a Pilot

Medications are assessed according to Transport Canada Civil Aviation Medicine guidance (SI 404-005). Both the underlying condition and effects of the medication are considered for flight safety.

Medication Quick Check Tool

Type a medication name to see general aviation guidance.

High-Risk Medications

These medications are generally not compatible with aviation safety. CAMEs may not renew a pilot on these medications unless previously approved and stable. If stopped, a washout period is required (typically ≥5 half-lives, may vary by drug).

• Alpha blockers (except BPH treatments)
• Anticholinergics (Scopolamine, Tolterodine, Oxybutynin)
• Antidepressants (most sedating; SSRI/SNRI may require approval)
• Antihistamines with sedating effects (Diphenhydramine, Dimenhydrinate)
• Anti-seizure, Antipsychotics, Anti-Parkinsonian meds
• Benzodiazepines, Sedatives (Zopiclone, Zolpidem)
• Opioids, Cannabis, Psychostimulants/ADHD medications
• Cancer chemotherapy/Immunomodulators
• Mood stabilizers, Muscle relaxants, Cardiac nitrates
• Systemic steroids, any medication warning against driving/flying

Rule of thumb: If you take any of these medications, consult a CAME before flying. Special protocols may exist in rare cases.

Low-Risk Medications

These are typically compatible with aviation if the underlying condition is stable, the medication is tolerated, and ground testing shows no impairment:

• Non-opioid analgesics (Acetaminophen, NSAIDs)
• Non-sedating antihistamines (Loratadine, Cetirizine, Fexofenadine)
• Antacids, proton pump inhibitors, antidiarrheals
• Antibiotics (most; consult RAMO for exceptions)
• Asthma medications if controlled (SABA/LABA, ICS)
• Hormone therapies (Estrogen, Androgen, Contraceptives)
• ED medications (Sildenafil, Vardenafil if no adverse effects)
• Lipid-lowering medications (statins, etc.)
• Nicotine replacement therapy
• Topical treatments and vitamin/mineral supplements

Even low-risk medications require CAME documentation of stability, dose, and absence of side effects.